One-pot three-component synthesis of a new series of tetrahydrobenzofuran-chromone conjugates
نویسندگان
چکیده
An efficient one-pot three-component protocol for the synthesis of novel tetrahydrobenzofuran-chromone conjugates using 3-formylchromones and 1,3-cyclohexandiones in presence a variety alkyl or aryl isocyanides was developed. The reaction sequence consists an initial Knoevenagel condensation aromatic aldehydes with 1,3-cyclohexandione derivatives, followed by [4 + 1] cycloaddition isocyanides, then imine-enamine tautomerization to afford products.
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ژورنال
عنوان ژورنال: Synthetic Communications
سال: 2021
ISSN: ['1532-2432', '0039-7911']
DOI: https://doi.org/10.1080/00397911.2021.1918169